Pharmaceuticals and biotechnology

In drug production, maximum output is essential. Whether handling and packaging of IV bags, syringes and vials, aseptic dispensing or loading and unloading of insulators, Stäubli robots score particularly well in terms of ultra-short cycle times.


TX60 cleanroom robot, automatic filling and closing of nested syringes and other nested objects.
Manual loading of nests on the rotary table.
TX60 cr, extending the capabilities of the system and bringing flexibility to all processes.
The machine guarding provides optimum user safety while ensuring ample access to the work stations.

Filling and closing machine for syringes

This innovative system for filling and closing syringes achieves a maximum output of up to 4,000 units per hour. The manufacturer uses a stainless steel machine with laminar-flow-friendly design incorporating an accurate TX60 cr robot.
In addition to boosting productivity versus glove boxes manual work the TX60 extends the capabilities of the system and brings flexibility to the handling, filling and closing processes. Thanks to the robot, they have even been able to integrate additional tasks into the cell.

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Stericlean robots from Stäubli facilitate automation processes under aseptic production conditions.
A Restricted Access Barrier System (RABS), enclosing a vial filling line.
An ANSI/RIA R15.06-1999 robot safety-compliant RABS unit protects the operator from the robot system and the product from contamination by the operator.

Robots in aseptic drug manufacturing

The manufacture of drugs poses particular challenges. In order to establish the highest safety standards, the industry relies on the so-called Advanced Aseptic Processing (AAP) system. This is a comprehensive package of measures aimed at systematically avoiding contamination whilst using the latest automation technologies.
With its TX stericlean series, Stäubli has developed the world’s first robot that can work permanently in aseptic production areas. This is due to its unique enclosed structure, to the use of stainless steel for stressed parts and to its special surface treatment. The process safety and reliability of the stericlean robot conform to the stringent requirements of the AAP system and ensure comprehensive protection of the product groups.

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The TX200 robot conveys the tray at high speed and with accuracy.
TX200 and RX160, a clever cooperation avoids production interruptions.
With Stäubli robots the loading of mesh crates is running without any problems for many years.
The smaller RX160 is handling the bags, while the TX200 exchanges the heavy trays.

Automatic packaging of parenteral bags

Two Stäubli robots demonstrate their cleanroom performance in a production line for the automatic filling and packing of parenteral bags. The smaller RX160 is responsible for handling the bags, while the larger TX200 exchanges the heavy trays.
To ensure that production is not interrupted, the CS8C robot controller for the TX200 coordinates all processes from buffering the bag feed to synchronizing all handling operations. In this way, continuous production is maintained.

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TX40, checking vials and ampoules for cosmetic and functional defects.
Robot based inspection modul RIM from Seidenader.
TX40, taking on the job of all handling tasks.
Double gripper, enabling various containers to be safely grasped with minimal format part changing.

Inspection of pharmaceutical drugs

The development of a new testing technology marks a new chapter in the inspection of pharmaceutical products. A compact Stäubli robot and a pioneering cell layout bring unprecedented flexibility into play, facilitating the automatic inspection of small batches. Centrally located within the module, a Stäubli six-axis robot takes care of all handling tasks.

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The IV Express production and filling line achieves a filling tolerance of +/- 1 %. Then the bag closes.
The fully automated plant can produce and fill well over 100,000 IV bags per day working in three shifts.
TX60 cleanroom class 5 offers unlimited flexibility and maximum output from minimum footprint.
Consistently high level of quality, hygiene, stringent clean room standards and high precision are the main criteria.

Manufacture and filling of infusion bags

The requirements for equipment used in the production of infusion bags with integrated filling are by no means straightforward: stringent quality and hygiene standards, systematic cleanroom suitability, unrestricted flexibility, maximum output and minimum demands on space. In a pioneering facility for the production and filling of infusion bags, a Stäubli TX60 ensures a consistent output of up to 7,200 units per hour. Even in its standard version, the robot already complies with the ISO 5 cleanroom classification and is therefore perfect for use at the filling stage.

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Cellmate’s robotic precision ensures each batch is processed identically, delivering reliable and reproducible results.
Cell culture in roller bottles.
The Stäubli robot arm closely mimics all the manual handling required for cell culture in roller bottles and T-flasks.
Cellmate – Incubator.
Cellmate incubator filled with roller bottles, full view.
Roller bottles on conveyor.
T-flask in decapper.
Handling of T-flasks by Stäubli TX60 cleanroom robot arm.

Large volume, single cell-line production

The Cellmate production line is an established system that fully automates all the processes needed to culture cells in roller bottles and T-flasks. It takes cell culture processing from the lab bench to high volume production without process change. The latest generation of Cellmate is supplied with software to support the validation of the system, if used in processes that require compliance with a 21 CFR Part 11.
The Stäubli highly precise TX60 cleanroom robot forming the core of the large volume, single cell-line production, guarantees a high product consistency day to day, batch to batch.

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Flexible, high-performance filling and closing machine for small batches with two clean room robots.
TX60 stericlean, the use of two Stäubli robots provides a wide range of applications.

Filling and Closing Machine for small batches

By the use of stericlean robots the flexible, high-performance filling and closing machine for small batches (KCP) provides a wide range of applications. Virtually any customary container can be processed here without major conversion times. Completely different work steps can be integrated in the work flow. Up to four work stations can be installed in the machine, these can easily be exchanged later by the operating staff as required. The configuration illustrated is equipped with a filling, stopper insertion and cap crimping station. The vials are brought to the individual work stations by the robots which can convey up to four containers at once. Up to 1000 containers per hour can be achieved with 100 per cent in-process-control.


Handling of containers and dosing of granulates by Stäubli TX90L cleanroom robot arm.
The Stäubli TX90L robot fully complies with the specification for cleanroom applications arm class ISO 5.

Mixing of granules in cleanroom

This autonomous production cell has a Stäubli TX90L articulated robot at its center. The robot operates the processing units, i.e. dosing, pressing stamping and the microwave oven. The robot performs the handling of containers and the mixing of granules. The customer friendly Human Machine Interface (HMI) allows the operator to adjust the various process parameters in line with new requirements, so that other products can easily be integrated at a later stage.
High availability and optimized processes enable cycle times to be kept to a minimum. If an error occurs at any stage, the defective item is automatically removed by the robot. This ensures that the end product leaving the production cell conforms to a consistent high quality. Automated production eliminates impurities.